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Homogeneous low-molecular-weight heparins with reversible anticoagulant activity
Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. We report a series of synthetic LMWHs prepared by cost-effective chemoenzymat...
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| Pubblicato in: | Nat Chem Biol |
|---|---|
| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4393012/ https://ncbi.nlm.nih.gov/pubmed/24561662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1459 |
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