Homogeneous low-molecular-weight heparins with reversible anticoagulant activity

Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. We report a series of synthetic LMWHs prepared by cost-effective chemoenzymat...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Xu, Yongmei, Cai, Chao, Chandarajoti, Kasemsiri, Hsieh, Po-Hung, Li, Lingyun, Pham, Truong Q, Sparkenbaugh, Erica M, Sheng, Juzheng, Key, Nigel S, Pawlinski, Rafal, Harris, Edward N, Linhardt, Robert J, Liu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4393012/
https://ncbi.nlm.nih.gov/pubmed/24561662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1459
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