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Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by a peripheral region determines their different sensitivity to warfarin inhibition
BACKGROUND: The human genome encodes two paralogs of vitamin-K-epoxide reductase, VKORC1 and VKORL1, that support blood coagulation and other vitamin-K-dependent processes. Warfarin inhibits both enzymes, but VKORL1 is relatively resistant to warfarin. OBJECTIVES: To understand the difference betwee...
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| Yayımlandı: | J Thromb Haemost |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6231229/ https://ncbi.nlm.nih.gov/pubmed/29665197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14127 |
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