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Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97
[Image: see text] Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported. The addition of an N-alkyl piperazine led to high potency of this series in a biochemical assay, activity in cell-based...
में बचाया:
में प्रकाशित: | ACS Med Chem Lett |
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मुख्य लेखकों: | , , , , , , , , , , , , , |
स्वरूप: | Artigo |
भाषा: | Inglês |
प्रकाशित: |
American Chemical
Society
2018
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ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6231190/ https://ncbi.nlm.nih.gov/pubmed/30429948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00372 |
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