Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97

[Image: see text] Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported. The addition of an N-alkyl piperazine led to high potency of this series in a biochemical assay, activity in cell-based...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: LaPorte, Matthew G., Burnett, James C., Colombo, Raffaele, Bulfer, Stacie L., Alverez, Celeste, Chou, Tsui-Fen, Neitz, R. Jeffrey, Green, Neal, Moore, William J., Yue, Zhizhou, Li, Shan, Arkin, Michelle R., Wipf, Peter, Huryn, Donna M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2018
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231190/
https://ncbi.nlm.nih.gov/pubmed/30429948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00372
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