The effects of CD14 and IL-27 on induction of endotoxin tolerance in human monocytes and macrophages

Upon repeated exposure to endotoxin or lipopolysaccharide (LPS), myeloid cells enter a refractory state called endotoxin tolerance as a homeostatic mechanism. In innate immune cells, LPS is recognized by co-receptors Toll-like receptor 4 (TLR4) and CD-14 to initiate an inflammatory response for subs...

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Опубликовано в: :J Biol Chem
Главные авторы: Petes, Carlene, Mintsopoulos, Victoria, Finnen, Renée L., Banfield, Bruce W., Gee, Katrina
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231135/
https://ncbi.nlm.nih.gov/pubmed/30242126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003501
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