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The effects of CD14 and IL-27 on induction of endotoxin tolerance in human monocytes and macrophages
Upon repeated exposure to endotoxin or lipopolysaccharide (LPS), myeloid cells enter a refractory state called endotoxin tolerance as a homeostatic mechanism. In innate immune cells, LPS is recognized by co-receptors Toll-like receptor 4 (TLR4) and CD-14 to initiate an inflammatory response for subs...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6231135/ https://ncbi.nlm.nih.gov/pubmed/30242126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003501 |
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