Persistent pulmonary hypertension alters the epigenetic characteristics of endothelial nitric oxide synthase gene in pulmonary artery endothelial cells in a fetal lamb model

Decreased expression of endothelial nitric oxide synthase (eNOS), a key mediator of perinatal transition, characterizes persistent pulmonary hypertension of the newborn (PPHN) in neonates and a fetal lamb model; the mechanisms are unclear. We investigated whether increased DNA CpG methylation at the...

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Detalhes bibliográficos
Publicado no:Physiol Genomics
Main Authors: Ke, Xingrao, Johnson, Hollis, Jing, Xigang, Michalkiewicz, Teresa, Huang, Yi-Wen, Lane, Robert H., Konduri, Girija G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230868/
https://ncbi.nlm.nih.gov/pubmed/30004838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00047.2018
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