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Protein Labeling via a Specific Lysine-Isopeptide Bond using the Pilin Polymerizing Sortase from Corynebacterium diphtheriae

Proteins that are site-specifically modified with peptides and chemicals can be used as novel therapeutics, imaging tools, diagnostic reagents and materials. However, there are few enzyme-catalyzed methods currently available to selectively conjugate peptides to internal sites within proteins. Here...

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Bibliografiska uppgifter
I publikationen:J Am Chem Soc
Huvudupphovsmän: McConnell, Scott A., Amer, Brendan R., Muroski, John, Fu, Janine, Chang, Chungyu, Ogorzalek Loo, Rachel R., Loo, Joseph A., Osipiuk, Jerzy, Ton-That, Hung, Clubb, Robert T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230430/
https://ncbi.nlm.nih.gov/pubmed/29927249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05200
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