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Evaluation and optimisation of unnatural amino acid incorporation and bioorthogonal bioconjugation for site-specific fluorescent labelling of proteins expressed in mammalian cells

Many biophysical techniques that are available to study the structure, function and dynamics of cellular constituents require modification of the target molecules. Site-specific labelling of a protein is of particular interest for fluorescence-based single-molecule measurements including single-mole...

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Bibliographic Details
Published in:Biochem Biophys Rep
Main Authors: Jakob, Leonhard, Gust, Alexander, Grohmann, Dina
Format: Artigo
Language:Inglês
Published: Elsevier 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226565/
https://ncbi.nlm.nih.gov/pubmed/30450427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2018.10.011
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