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Liquid and Hydrogel Phases of PrP(C) Linked to Conformation Shifts and Triggered by Alzheimer’s Amyloid-β Oligomers

Protein phase separation by low complexity, intrinsically disordered domains generates membraneless organelles and links to neurodegeneration. Cellular prion protein (PrP(C)) contains such domains, causes spongiform degeneration and is a receptor for Alzheimer’s amyloid-β oligomers (Aβo). Here, we s...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Mol Cell
मुख्य लेखकों: Kostylev, Mikhail A., Tuttle, Marcus D., Lee, Suho, Klein, Lauren E., Takahashi, Hideyuki, Cox, Timothy O., Gunther, Erik C., Zilm, Kurt W., Strittmatter, Stephen M.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226277/
https://ncbi.nlm.nih.gov/pubmed/30401430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.10.009
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