A New Strategy for Rapidly Screening Natural Inhibitors Targeting the PCSK9/LDLR Interaction In Vitro

The interaction between proprotein convertase subtilisin/kexin type 9 (PCSK9) and the low-density lipoprotein receptor (LDLR) is a promising target for the treatment of hyperc-holesterolemia. In this study, a new method based on competitive affinity and tag detection was developed, which aimed to ev...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Li, Li, Shen, Chen, Huang, Ya-Xuan, Li, Ya-Nan, Liu, Xiu-Feng, Liu, Xu-Ming, Liu, Ji-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225438/
https://ncbi.nlm.nih.gov/pubmed/30235833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23092397
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