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Direct Asymmetric Reductive Amination for the Synthesis of (S)-Rivastigmine
In this article we demonstrate how asymmetric total synthesis of (S)-rivastigmine has been achieved using direct asymmetric reductive amination as the key transformation in four steps. The route started with readily available and cheap m-hydroxyacetophenone, through esterification, asymmetric reduct...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6225309/ https://ncbi.nlm.nih.gov/pubmed/30200331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23092207 |
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