Low-Dose Radiation Conditioning Enables CAR T Cells to Mitigate Antigen Escape

CD19 chimeric antigen receptors (CARs) have demonstrated great efficacy against a range of B cell malignancies. However, antigen escape and, more generally, heterogeneous antigen expression pose a challenge to applying CAR therapy to a wide range of cancers. We find that low-dose radiation sensitize...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: DeSelm, Carl, Palomba, M. Lia, Yahalom, Joachim, Hamieh, Mohamad, Eyquem, Justin, Rajasekhar, Vinagolu K., Sadelain, Michel
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2018
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225039/
https://ncbi.nlm.nih.gov/pubmed/30415658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.09.008
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