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Characterization of TDP-43 RRM2 Partially Folded States and Their Significance to ALS Pathogenesis
The human protein TDP-43 is a major component of the cellular aggregates found in amyotrophic lateral sclerosis and other neurodegenerative diseases. Insoluble cytoplasmic aggregates isolated from the brain of amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients contain ubiqu...
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| 發表在: | Biophys J |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Biophysical Society
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6224623/ https://ncbi.nlm.nih.gov/pubmed/30309612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.09.011 |
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