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Characterization of TDP-43 RRM2 Partially Folded States and Their Significance to ALS Pathogenesis

The human protein TDP-43 is a major component of the cellular aggregates found in amyotrophic lateral sclerosis and other neurodegenerative diseases. Insoluble cytoplasmic aggregates isolated from the brain of amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients contain ubiqu...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Tavella, Davide, Zitzewitz, Jill A., Massi, Francesca
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224623/
https://ncbi.nlm.nih.gov/pubmed/30309612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.09.011
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