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Characterization of TDP-43 RRM2 Partially Folded States and Their Significance to ALS Pathogenesis

The human protein TDP-43 is a major component of the cellular aggregates found in amyotrophic lateral sclerosis and other neurodegenerative diseases. Insoluble cytoplasmic aggregates isolated from the brain of amyotrophic lateral sclerosis and frontotemporal lobar degeneration patients contain ubiqu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Tavella, Davide, Zitzewitz, Jill A., Massi, Francesca
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224623/
https://ncbi.nlm.nih.gov/pubmed/30309612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.09.011
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