Folding of the RNA Recognition Motif (RRM) Domains of the Amyotrophic Lateral Sclerosis (ALS)-linked Protein TDP-43 Reveals an Intermediate State

Pathological alteration of TDP-43 (TAR DNA-binding protein-43), a protein involved in various RNA-mediated processes, is a hallmark feature of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Fragments of TDP-43, composed of the second RNA recogniti...

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Bibliografiske detaljer
Main Authors: Mackness, Brian C., Tran, Meme T., McClain, Shannan P., Matthews, C. Robert, Zitzewitz, Jill A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961654/
https://ncbi.nlm.nih.gov/pubmed/24497641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.542779
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