Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations

Aging human tissues, such as sun-exposed epidermis, accumulate a high burden of progenitor cells that carry oncogenic mutations. However, most progenitors carrying such mutations colonize and persist in normal tissue without forming tumors. Here, we investigated tissue-level constraints on clonal pr...

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Udgivet i:Cell Stem Cell
Main Authors: Murai, Kasumi, Skrupskelyte, Greta, Piedrafita, Gabriel, Hall, Michael, Kostiou, Vasiliki, Ong, Swee Hoe, Nagy, Tibor, Cagan, Alex, Goulding, David, Klein, Allon M., Hall, Benjamin A., Jones, Philip H.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224607/
https://ncbi.nlm.nih.gov/pubmed/30269904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.08.017
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