Novel Antibody Drug Conjugates Targeting Tumor-Associated Receptor Tyrosine Kinase ROR2 by Functional Screening of Fully Human Antibody Libraries Using Transpo-mAb Display on Progenitor B Cells

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) has been identified as a highly relevant tumor-associated antigen in a variety of cancer indications of high unmet medical need, including renal cell carcinoma and osteosarcoma, making it an attractive target for targeted cancer therapy. Here, w...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Hellmann, Ina, Waldmeier, Lorenz, Bannwarth-Escher, Marie-Christine, Maslova, Kseniya, Wolter, Fabian I., Grawunder, Ulf, Beerli, Roger R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224377/
https://ncbi.nlm.nih.gov/pubmed/30450096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02490
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