Generation of an artificial human B cell line test system using Transpo-mAb(TM) technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins

The antigen-specific targeting of autoreactive B cells via their unique B cell receptors (BCRs) is a novel and promising alternative to the systemic suppression of humoral immunity. We generated and characterized cytolytic fusion proteins based on an existing immunotoxin comprising tetanus toxoid fr...

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Pubblicato in:PLoS One
Autori principali: Klose, Diana, Woitok, Mira, Niesen, Judith, Beerli, Roger R., Grawunder, Ulf, Fischer, Rainer, Barth, Stefan, Fendel, Rolf, Nachreiner, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509223/
https://ncbi.nlm.nih.gov/pubmed/28704435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180305
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