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Density Functional Studies on Secondary Amides: Role of Steric Factors in Cis/Trans Isomerization

Cis/trans isomerization of amide bonds is a key step in a wide range of biological and synthetic processes. Occurring through C-N amide bond rotation, it also coincides with the activation of amides in enzymatic hydrolysis. In recently described QM studies of cis/trans isomerization in secondary ami...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Thakkar, Balmukund S., Svendsen, John Sigurd M., Engh, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222500/
https://ncbi.nlm.nih.gov/pubmed/30257481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23102455
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