Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice

The contributions of maternal diet and obesity in shaping offspring microbiome remain unclear. Here we employed a mouse model of maternal diet-induced obesity via high-fat diet feeding (HFD, 45% fat calories) for 12 wk prior to conception on offspring gut microbial ecology. Male and female offspring...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Wankhade, Umesh D., Zhong, Ying, Kang, Ping, Alfaro, Maria, Chintapalli, Sree V., Piccolo, Brian D., Mercer, Kelly E., Andres, Aline, Thakali, Keshari M., Shankar, Kartik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6220325/
https://ncbi.nlm.nih.gov/pubmed/30405201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34453-0
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