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Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is an important co-morbidity associated with obesity and a precursor to steatohepatitis. However, the contributions of gestational and early life influences on development of NAFLD and NASH remain poorly appreciated. METHODS: Two independent studi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Wankhade, Umesh D., Zhong, Ying, Kang, Ping, Alfaro, Maria, Chintapalli, Sree V., Thakali, Keshari M., Shankar, Kartik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393586/
https://ncbi.nlm.nih.gov/pubmed/28414763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175675
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