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De novo design of a non-local β-sheet protein with high stability and accuracy
β-sheet proteins carry out critical functions in biology, and hence are attractive scaffolds for computational protein design. Despite this potential, de novo design of all β-sheet proteins from first principles lags far behind the design of all-α or mixed αβ domains due to their non-local nature an...
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| Publicado en: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219906/ https://ncbi.nlm.nih.gov/pubmed/30374087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0141-6 |
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