Memory inflation following adenoviral vaccination depends on IL-21

Cytomegalovirus (CMV) and non-replicating adenoviral vectors can induce expanded, sustained effector-memory CD8(+) T-cell responses, termed “memory inflation”. During murine CMV (MCMV) infection, CD4(+) Tcells maintain inflationary virus-specific CD8(+) T-cell responses via IL-2 but not IL-21. Adeno...

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Publicado en:Vaccine
Main Authors: Gordon, Claire L., Hutchings, Claire L., Highton, Andrew J., Colston, Julia M., Provine, Nicholas M., Klenerman, Paul
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219444/
https://ncbi.nlm.nih.gov/pubmed/30279090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2018.09.061
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