Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress

The DNA helicase FANCJ is mutated in hereditary breast and ovarian cancer and Fanconi anemia (FA). Nevertheless, how loss of FANCJ translates to disease pathogenesis remains unclear. We addressed this question by analyzing proteins associated with replication forks in cells with or without FANCJ. We...

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Foilsithe in:Cell Rep
Main Authors: Peng, Min, Cong, Ke, Panzarino, Nicholas J., Nayak, Sumeet, Calvo, Jennifer, Deng, Bin, Zhu, Lihua Julie, Morocz, Monika, Hegedus, Lili, Haracska, Lajos, Cantor, Sharon B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218949/
https://ncbi.nlm.nih.gov/pubmed/30232006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.065
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