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Radical/Polar Annulation Reactions (RPARs) Enable the Modular Construction of Cyclopropanes

An annulation process for the construction of 1,1-disubstituted cyclopropanes via a radical/polar crossover process is described. The cyclopropanation proceeds by the addition of a photocatalytically generated radical to a homoallylic tosylate. Reduction of the intermediate radical alkylation adduct...

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Bibliografiske detaljer
Udgivet i:Org Lett
Main Authors: Milligan, John A., Phelan, James P., Polites, Viktor C., Kelly, Christopher B., Molander, Gary A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218941/
https://ncbi.nlm.nih.gov/pubmed/30350660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b02968
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