A novel FADS2 isoform identified in human milk fat globule suppresses FADS2 mediated Δ6-desaturation of omega-3 fatty acids

INTRODUCTION. The only known non-pharmacological means to alter long chain polyunsaturated fatty acid (LCPUFA) abundance in mammalian tissue is by altering substrate fatty acid ratios. Alternative mRNA splicing is increasingly recognized as a modulator of protein structure and function. Here we repo...

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Veröffentlicht in:Prostaglandins Leukot Essent Fatty Acids
Hauptverfasser: Kothapalli, Kumar S. D., Park, Hui Gyu, Guo, Xiaoxian, Sun, Xuepeng, Zou, James, Hyon, Stephanie S., Qin, Xia, Lawrence, Peter, Ran-Ressler, Rinat R., Zhang, Ji Yao, Gu, Zhenglong, Brenna, J. Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218299/
https://ncbi.nlm.nih.gov/pubmed/30041907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.plefa.2018.06.004
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