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The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells

Docosahexaenoic acid (DHA) is a Δ4-desaturated C22 fatty acid and the limiting highly unsaturated fatty acid (HUFA) in neural tissue. The biosynthesis of Δ4-desaturated docosanoid fatty acids 22:6n-3 and 22:5n-6 are believed to proceed via a circuitous biochemical pathway requiring repeated use of a...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Park, Hui Gyu, Park, Woo Jung, Kothapalli, Kumar S. D., Brenna, J. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550368/
https://ncbi.nlm.nih.gov/pubmed/26065859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271783
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