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Identifying Novel Enhancer Elements with CRISPR-Based Screens

Enhancers control the spatiotemporal expression of genes and are essential for encoding differentiation and development. Since their discovery more than three decades ago, researchers have largely studied enhancers removed from their genomic context. The recent adaptation of CRISPR/Cas9 to genome ed...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Klein, Jason C., Chen, Wei, Gasperini, Molly, Shendure, Jay
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218247/
https://ncbi.nlm.nih.gov/pubmed/29300083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00778
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