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Identifying Novel Enhancer Elements with CRISPR-Based Screens

Enhancers control the spatiotemporal expression of genes and are essential for encoding differentiation and development. Since their discovery more than three decades ago, researchers have largely studied enhancers removed from their genomic context. The recent adaptation of CRISPR/Cas9 to genome ed...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Klein, Jason C., Chen, Wei, Gasperini, Molly, Shendure, Jay
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218247/
https://ncbi.nlm.nih.gov/pubmed/29300083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00778
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