In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease

Diffusible amyloid-β (Aβ) oligomers are currently presumed to be the most cytotoxic Aβ assembly and held responsible to trigger the pathogenesis of Alzheimer’s disease (AD). Thus, Aβ oligomers are a prominent target in AD drug development. Previously, we reported on our solely D-enantiomeric peptide...

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Detalles Bibliográficos
Publicado en:J Alzheimers Dis
Main Authors: Schartmann, Elena, Schemmert, Sarah, Niemietz, Nicole, Honold, Dominik, Ziehm, Tamar, Tusche, Markus, Elfgen, Anne, Gering, Ian, Brener, Oleksandr, Shah, Nadim Joni, Langen, Karl-Josef, Kutzsche, Janine, Willbold, Dieter, Willuweit, Antje
Formato: Artigo
Idioma:Inglês
Publicado: IOS Press 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218115/
https://ncbi.nlm.nih.gov/pubmed/29966196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-180165
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