Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

Targeting toxic amyloid beta (Aβ) oligomers is currently a very attractive drug development strategy for treatment of Alzheimer´s disease. Using mirror-image phage display against Aβ1-42, we have previously identified the fully D-enantiomeric peptide D3, which is able to eliminate Aβ oligomers and h...

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Foilsithe in:PLoS One
Main Authors: Jiang, Nan, Leithold, Leonie H. E., Post, Julia, Ziehm, Tamar, Mauler, Jörg, Gremer, Lothar, Cremer, Markus, Schartmann, Elena, Shah, N. Jon, Kutzsche, Janine, Langen, Karl-Josef, Breitkreutz, Jörg, Willbold, Dieter, Willuweit, Antje
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457900/
https://ncbi.nlm.nih.gov/pubmed/26046986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128553
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