Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis

The potent antimalarial drug pyronaridine (PND) was tested for its potential as an anticancer drug. After exposing cancerous (17) and non-cancerous (2) cells to PND for 72 hr, PND was found to exhibit consistent and potent cytotoxic activity at low micromolar (μM) concentrations that ranged from 1.6...

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Опубликовано в: :PLoS One
Главные авторы: Villanueva, Paulina J., Martinez, Alberto, Baca, Sarah T., DeJesus, Rebecca E., Larragoity, Manuel, Contreras, Lisett, Gutierrez, Denisse A., Varela-Ramirez, Armando, Aguilera, Renato J.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218039/
https://ncbi.nlm.nih.gov/pubmed/30395606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206467
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