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Structural Studies Reveal an Important Role for the Pleiotrophin C Terminus in Mediating Interactions with Chondroitin Sulfate

Pleiotrophin (PTN) is a potent glycosaminoglycan-binding cytokine important in neural development, angiogenesis and tissue regeneration. Much of its activity is attributed to its interactions with the chondroitin sulfate (CS) proteoglycan, receptor type protein tyrosine phosphatase ζ (PTPRZ). Howeve...

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Publicado en:FEBS J
Autores principales: Ryan, Eathen, Shen, Di, Wang, Xu
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217956/
https://ncbi.nlm.nih.gov/pubmed/26896299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13686
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