PDTM-20. ELUCIDATING MOLECULAR PATHOGENIC MECHANISMS OF THE HISTONE H3.3 G34R MUTATION IN PEDIATRIC HIGH-GRADE GLIOMAS (HGGs)

High-grade glioma (HGG) is the most common and lethal type of primary brain tumor in humans, remaining essentially incurable; 16% of pediatric and young adult HGGs in cerebral hemispheres encode Gly34Arg/Val (G34R/V) substitutions in the histone variant H3.3. It was shown that H3.3G34R/V leads to a...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Haase, Santiago, Belén Garcia-Fabiani, María, Nunez, Felipe, Kadiyala, Padma, Nunez, Fernando, Lowenstein, Pedro, Castro, Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217660/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.862
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