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PDTM-22. TARGETING A NOVEL METABOLIC DEFECT IN PPM1D-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMAS

Somatic truncating mutations within the oncogenic phosphatase PPM1D, have been identified in diffuse intrinsic pontine glioma (DIPG) and other high grade pediatric brain tumors. These stabilizing mutations result in an overabundance of the mutant protein within tumor cells, and inactivation of impor...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Fons, Nathan, Sundaram, Ranjini, Breuer, Greg, Brenner, Charles, Bindra, Ranjit
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217648/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.864
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