PDTM-29. TRANSCRIPTIONAL DEPENDENCIES IN DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using...

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Publicado en:Neuro Oncol
Main Authors: Nagaraja, Surya, Vitanza, Nicholas, Woo, Pamelyn, Taylor, Kathryn, Liu, Fang, Zhang, Lei, Li, Meng, Meng, Wei, Ponnuswami, Anitha, Sun, Wenchao, Ma, Jie, Hulleman, Esther, Swigut, Tomek, Wysocka, Joanna, Tang, Yujie, Monje-Deisseroth, Michelle
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
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Abstracts
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692690/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.793
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