Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using...

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Pubblicato in:Cancer Cell
Autori principali: Nagaraja, Surya, Vitanza, Nicholas A., Woo, Pamelyn, Taylor, Kathryn R., Liu, Fang, Zhang, Lei, Li, Meng, Meng, Wei, Ponnuswami, Anitha, Sun, Wenchao, Ma, Jie, Hulleman, Esther, Swigut, Tomek, Wysocka, Joanna, Tang, Yujie, Monje, Michelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462626/
https://ncbi.nlm.nih.gov/pubmed/28434841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.03.011
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