Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Nagaraja, Surya, Vitanza, Nicholas A., Woo, Pamelyn, Taylor, Kathryn R., Liu, Fang, Zhang, Lei, Li, Meng, Meng, Wei, Ponnuswami, Anitha, Sun, Wenchao, Ma, Jie, Hulleman, Esther, Swigut, Tomek, Wysocka, Joanna, Tang, Yujie, Monje, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462626/
https://ncbi.nlm.nih.gov/pubmed/28434841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.03.011
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