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Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma
Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using...
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| Pubblicato in: | Cancer Cell |
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| Autori principali: | , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5462626/ https://ncbi.nlm.nih.gov/pubmed/28434841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.03.011 |
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