Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using...

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Publicat a:Cancer Cell
Autors principals: Nagaraja, Surya, Vitanza, Nicholas A., Woo, Pamelyn, Taylor, Kathryn R., Liu, Fang, Zhang, Lei, Li, Meng, Meng, Wei, Ponnuswami, Anitha, Sun, Wenchao, Ma, Jie, Hulleman, Esther, Swigut, Tomek, Wysocka, Joanna, Tang, Yujie, Monje, Michelle
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462626/
https://ncbi.nlm.nih.gov/pubmed/28434841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.03.011
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