Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Cell
Egile Nagusiak: Nagaraja, Surya, Vitanza, Nicholas A., Woo, Pamelyn, Taylor, Kathryn R., Liu, Fang, Zhang, Lei, Li, Meng, Meng, Wei, Ponnuswami, Anitha, Sun, Wenchao, Ma, Jie, Hulleman, Esther, Swigut, Tomek, Wysocka, Joanna, Tang, Yujie, Monje, Michelle
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462626/
https://ncbi.nlm.nih.gov/pubmed/28434841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.03.011
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