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PDTM-22. TARGETING A NOVEL METABOLIC DEFECT IN PPM1D-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMAS
Somatic truncating mutations within the oncogenic phosphatase PPM1D, have been identified in diffuse intrinsic pontine glioma (DIPG) and other high grade pediatric brain tumors. These stabilizing mutations result in an overabundance of the mutant protein within tumor cells, and inactivation of impor...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6217648/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.864 |
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