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PDTM-22. TARGETING A NOVEL METABOLIC DEFECT IN PPM1D-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMAS
Somatic truncating mutations within the oncogenic phosphatase PPM1D, have been identified in diffuse intrinsic pontine glioma (DIPG) and other high grade pediatric brain tumors. These stabilizing mutations result in an overabundance of the mutant protein within tumor cells, and inactivation of impor...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Neuro Oncol |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6217648/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.864 |
| Tagiau: |
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