RBTT-03. A PHASE 1, MULTICENTER, RANDOMIZED, OPEN-LABEL, PERIOPERATIVE STUDY OF AG-120 (IVOSIDENIB) AND AG-881 IN PATIENTS WITH RECURRENT, NONENHANCING, IDH1-MUTANT, LOW-GRADE GLIOMA

Mutations in isocitrate dehydrogenase (mIDH) are common in lower-grade glioma (LGG; mIDH1, 80%; mIDH2, 4%) and lead to epigenetic and genetic changes that promote oncogenesis via production of the oncometabolite 2-hydroxyglutarate (2-HG). AG-120 (ivosidenib) is a first-in-class oral mIDH1 inhibitor...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Mellinghoff, Ingo, Maher, Elizabeth, Wen, Patrick, Cloughesy, Timothy, Peters, Katherine, Choi, Changho, Ellingson, Benjamin, Lin, Alexander, Li, Yan, Soher, Brian, Young, Robert, Steelman, Lori, Le, Kha, Yin, Feng, Wu, Bin, Lu, Min, Zhang, Yanwei, Nicolay, Brandon, Schoenfeld, Steven, Yen, Katharine, Pandya, Shuchi, Clarke, Jennifer
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217633/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.973
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