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Thermodynamic favorability and pathway yield as evolutionary tradeoffs in biosynthetic pathway choice

The structure of the metabolic network contains myriad organism-specific variations across the tree of life, but the selection basis for pathway choices in different organisms is not well understood. Here, we examined the metabolic capabilities with respect to cofactor use and pathway thermodynamics...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Du, Bin, Zielinski, Daniel C., Monk, Jonathan M., Palsson, Bernhard O.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217407/
https://ncbi.nlm.nih.gov/pubmed/30309961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805367115
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