Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1

Mutations affecting the spliceosomal protein U2AF1 are commonly found in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML). We have generated mice that carry Cre-dependent knock-in alleles of U2af1(S34F), the murine version of the most common mutant allele of U2AF1 encounte...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Fei, Dennis Liang, Zhen, Tao, Durham, Benjamin, Ferrarone, John, Zhang, Tuo, Garrett, Lisa, Yoshimi, Akihide, Abdel-Wahab, Omar, Bradley, Robert K., Liu, Paul, Varmus, Harold
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217397/
https://ncbi.nlm.nih.gov/pubmed/30322915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812669115
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