EXTH-51. C18-CERAMIDE ANALOGUE DRUG OVERCOMES RESISTANCE TO TEMOZOLOMIDE IN GLIOBLASTOMA

Glioblastoma (GB) is a WHO Grade IV brain tumor with very limited therapeutic option currently available. The DNA-alkylating agent temozolomide (TMZ) is currently the most effective chemotoxic drug for GB therapy but efficacy tends to be short-lasting with tumors eventually becoming resistant to tre...

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Vydáno v:Neuro Oncol
Hlavní autoři: Das, Arabinda, Zdzislaw, Szulc, Cachia, David, Patel, Sunil J, Ogretmen, Besim
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217372/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.399
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