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IMMU-10. RADIOTHERAPY AND PD-1 BLOCKADE INCREASES TRYPTOPHAN METABOLISM IN BRAIN TUMOR-DRAINING SECONDARY LYMPHOID ORGANS
INTRODUCTION: Glioblastoma (GBM) is an aggressive, incurable, primary brain tumor with a median survival of 15–20 months. High intratumoral expression of indoleamine 2,3-dioxygenase 1 (IDO1), an immunosuppressive enzyme that metabolizes tryptophan (Trp) into kynurenine (Kyn), is one factor that cont...
Tallennettuna:
| Julkaisussa: | Neuro Oncol |
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| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6217352/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.513 |
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