TMIC-50. HYPERACTIVATING THE HIPPO PATHWAY EFFECTOR TAZ DISTORTS THE TUMOR MICROENVIRONMENT, PROMOTES TUMOR-ENTRAINED NEUTROPHIL INFILTRATION, AND PHENOCOPIES MESENCHYMAL-GLIOBLASTOMA

Glioblastoma (GBM), the deadliest and most common primary CNS malignancy in adults, is highly heterogeneous with variable prognoses and treatment responses. The molecular underpinnings for such variability remain largely unclear. Mesenchymal (MES)-GBMs, associated with poorest prognosis and highest...

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Publicado en:Neuro Oncol
Main Authors: Yee, Patricia, Liu, Zhijun, Wei, Yiju, Gulley, Melissa, Li, Wei
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217124/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1109
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