CMET-46. INITIAL CLINICAL AND ADVANCED IMAGING OUTCOMES FROM A MULTI-INSTITUTIONAL PHASE I DOSE-ESCALATION TRIAL OF RRX-001 PLUS WHOLE BRAIN RADIATION FOR PATIENTS WITH BRAIN METASTASES

BACKGROUND: RRx-001, a novel redox modulator was evaluated as a potential radiosensitizer with WBRT in a multicenter phase I trial for adults with brain metastases. The primary endpoint was to determine MTD. Secondary endpoints included intracranial response rate (IRR), survival and correlation of D...

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Publicado en:Neuro Oncol
Main Authors: Kim, Michelle, Parmar, Hemant, Aryal, Madhava, Schipper, Matthew, Devasia, Theresa, Kesari, Santosh, Morikawa, Aki, Spratt, Daniel, Junck, Larry, Hayman, James, Lawrence, Theodore, Tsien, Christina, Aiken, Robert, Goyal, Sharad, Knox, Susan, Caroen, Scott, Carter, Corey, Oronsky, Bryan, Cao, Yue, Lao, Christopher
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217024/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.255
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