CADD-16. DUAL PI3K/Akt INHIBITION TO OVERCOME THE P-gp/BCRP DRUG EFFLUX SYSTEM FOR IMPROVED DRUG DELIVERY IN GLIOBLASTOMA THERAPY

The blood-brain barrier is a primary obstacle for effective anticancer drug therapy of patients with glioblastoma multiforme (GBM). On a molecular level, failure of anticancer drug treatment is largely due to the blood-brain barrier efflux transporters P-glycoprotein (P-gp) and Breast Cancer Resista...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Hartz, Anika, Schulz, Julia, Sokola, Brent, Bauer, Bjoern
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Abstracts
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216818/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1161
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