NIMG-46. LONGITUDINAL RESTING-STATE FUNCTIONAL CONNECTIVITY CONFIRMS MARIZOMIB (MRZ) CROSSES THE BLOOD BRAIN BARRIER (BBB) AND CORRELATES WITH HALLUCINATION SEVERITY IN RECURRENT GBM PATIENTS

INTRODUCTION: MRZ is a second-generation, irreversible proteasome inhibitor currently in clinical trials for GBM. MRZ has ability to cross the BBB in animal models. CNS side-effects (including hallucinations and cerebellar ataxia) are both common adverse events. Here we report on the regional fMRI-d...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Keator, David B, G. Bota, Robert, L. Small, Steven, Bota, Daniela A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216278/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.772
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