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STEM-20. Spt6 REGULATES TRANSCRIPTION BY STABILIZING RNA Pol II AND SO DRIVES GLIOBLASTOMA CANCER STEM-LIKE CELL MAINTENANCE
Glioblastoma (GBM) is the most advanced and lethal tumor with epigenetically distinct cancer stem-like cells (CSCs) resistant to chemo- and radio-therapy. Spt6 is a histone chaperon involved in nucleosome assembly and regulates RNA polymerase II-mediated transcription. Our preliminary data identifie...
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| Publicado en: | Neuro Oncol |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216212/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.1027 |
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