ATIM-32. PERSONALIZED NEOANTIGEN-TARGETING VACCINE GENERATES ROBUST SYSTEMIC AND INTRATUMORAL T CELL RESPONSES IN GLIOBLASTOMA (GBM) PATIENTS

BACKGROUND: The impact of individualized neoepitope vaccination targeting neoantigens arising from tumor-specific mutations for GBM, a low mutation burden tumor with an immunologically cold tumor microenvironment, as well as that of concurrently administered dexamethasone (dex), are unknown. METHODS...

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Publicado no:Neuro Oncol
Main Authors: Reardon, David, Keskin, Derin, Tirosh, Itay, Anandappa, Annabelle, Mathewson, Nathan, Sun, Jing, Shukla, Sachet, Gjini, Evisa, Li, Shuqiang, Giobbie-Hurder, Anita, McCluskey, Christine, Chiocca, E Antonio, Neuberg, Donna, Wucherpfennig, Kai, Suva, Mario, Fritsch, Edward, Rodig, Scott, Ligon, Keith, Wen, Patrick, Livak, Kenneth, Regev, Aviv, Hacohen, Nir, Wu, Catherine, Ott, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216142/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.027
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