A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens

Recent studies have highlighted the promise of targeting tumor neoantigens to generate potent antitumor immune responses and provide strong motivation for improving our understanding of antigen-T-cell receptor (TCR) interactions. Advances in single-cell sequencing technologies have opened the door f...

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Vydáno v:Blood
Hlavní autoři: Hu, Zhuting, Anandappa, Annabelle J., Sun, Jing, Kim, Jintaek, Leet, Donna E., Bozym, David J., Chen, Christina, Williams, Louise, Shukla, Sachet A., Zhang, Wandi, Tabbaa, Diana, Steelman, Scott, Olive, Oriol, Livak, Kenneth J., Kishi, Hiroyuki, Muraguchi, Atsushi, Guleria, Indira, Stevens, Jonathan, Lane, William J., Burkhardt, Ute E., Fritsch, Edward F., Neuberg, Donna, Ott, Patrick A., Keskin, Derin B., Hacohen, Nir, Wu, Catherine J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Immunobiology and Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213317/
https://ncbi.nlm.nih.gov/pubmed/30150207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-843763
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