A cloning and expression system to probe T-cell receptor specificity and assess functional avidity to neoantigens

Recent studies have highlighted the promise of targeting tumor neoantigens to generate potent antitumor immune responses and provide strong motivation for improving our understanding of antigen-T-cell receptor (TCR) interactions. Advances in single-cell sequencing technologies have opened the door f...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Hu, Zhuting, Anandappa, Annabelle J., Sun, Jing, Kim, Jintaek, Leet, Donna E., Bozym, David J., Chen, Christina, Williams, Louise, Shukla, Sachet A., Zhang, Wandi, Tabbaa, Diana, Steelman, Scott, Olive, Oriol, Livak, Kenneth J., Kishi, Hiroyuki, Muraguchi, Atsushi, Guleria, Indira, Stevens, Jonathan, Lane, William J., Burkhardt, Ute E., Fritsch, Edward F., Neuberg, Donna, Ott, Patrick A., Keskin, Derin B., Hacohen, Nir, Wu, Catherine J.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2018
Sujets:
Immunobiology and Immunotherapy
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6213317/
https://ncbi.nlm.nih.gov/pubmed/30150207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-843763
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